Reduced Polio Vaccine Doses Deliver Similar Protection
A new study published by The Lancet on April 30, 2021, reviewed data comparing the effects of fractional Vs. Full-dose inactivated poliovirus vaccine (IPV) vaccination to determine when seroconversion proportions with each strategy become similar in children aged 5 years and younger.
In this systematic review and meta-analysis from 16 databases, these researchers concluded 'There is no substantial difference in seroconversion between three doses of fractional-IPV and three doses of full-dose IPV.
However, the full dosage empowers higher titers of antibodies for poliovirus type 1, 2, and 3.
On April 28, 2021, the Global Polio Eradication Initiative reported additional African, Middle East, and Asia countries are confirming new polio cases during 2021.
Since 2000, IPV is most often given in the USA, which seldom confirms local polio cases.