Rabies Vaccines

Authored by
Last reviewed
April 1, 2021

Rabies Vaccines

The rabies vaccine is used to prevent rabies. There are several rabies vaccines available worldwide that are both safe and effective.

They can be used to prevent rabies before and for a period of time after exposure to the rabies virus, which is commonly caused by a dog bite or a bat bite.

In the search for novel rabies control and treatment strategies, live-attenuated viruses have recently emerged as a practical and promising approach for immunizing and controlling rabies.

Unlike the conventional, inactivated rabies vaccine, live-attenuated viruses are genetically modified viruses that can replicate in an inoculated recipient without causing adverse effects while still eliciting robust and effective immune responses against rabies virus infection.

Available Rabies Vaccines

Chirorab, previously known as Rabipur, is an inactivated rabies virus of the strain Flury LEP. Chiron Behring Vaccines is re-launching Rabipur, a purified chick embryo cell (PCEC) vaccine. It will continue to be manufactured at its WHO pre-qualified facility in Ankleshwar Gujarat, India.

Imovax Rabies is an inactivated vaccine made from an attenuated rabies virus. It is a sterile, stable, freeze-dried suspension of Rabies Vaccine Inactivated virus prepared from WISTAR Rabies PM/WI 38 1503-3M strain.

RabAvert is a vaccine that contains an inactivated rabies antigen. Bavarian Nordic's RabAvert vaccine is indicated for preexposure vaccination, in both primary and booster doses, and for postexposure prophylaxis against rabies in all age groups.

Rabivax-S is a lyophilized vaccine manufactured by Serum Institute of India Pvt. Ltd., containing inactivated purified rabies antigen. Rabivax-S has been developed on Vero ATCC CCL81 cells using Pitman Moore (PM3218) strain. It is an inactivated vaccine that is freeze-dried until ready for immunization.

Rabies Vaccine News

February 26, 2021 - The U.S. CDC’s ACIP Committee voted during a digital meeting to reduce the recommendation for rabies PrEP to a two-dose vaccine schedule, aligning with international guidance. The WHO also recommends a two-dose vaccination schedule.

February 13, 2021 - Researchers found an existing rabies treatment known as KEDRAB to be safe and effective for patients aged 17 and under. This study demonstrates that HRIG150 is well tolerated and effective in pediatric patients as a PEP component. This study is the first to establish pediatric safety and efficacy of HRIG in the US to the authors' knowledge.

February 6, 2021 - The Lancet published an editorial: Time to revise the Gavi funding strategy of rabies vaccine? 'In the long term, however, elimination of almost all human rabies could only be achieved by comprehensive vaccination of stray dogs.'

January 27, 2021 - The South Padre Island Animal Control Division city assisted the Texas Department of State Health Services Zoonosis Control Division with the Oral Rabies Vaccination Program. The city said the program aims to reduce the dog strain of rabies carried by coyotes in Texas. Vaccination for rabies will be distributed around the city in non-populated areas that may attract coyotes.

January 8, 2020 - A biopharmaceutical company announced positive data from its Phase 1 clinical trial evaluating CV7202, a novel prophylactic mRNA-based rabies vaccine. In this small study, all subjects who received 2-doses of 1 µg mRNA vaccine, the lowest dose tested, demonstrated a robust adaptive immune response with protective virus-neutralizing antibody titers levels above the threshold recommended by the World Health Organization.

July 12, 2019 - Bats are responsible for about 70 percent of rabies deaths among people infected with the USA's rabies virus, reports the Centers for Disease Control and Prevention. The CDC says 23 human rabies cases have been reported in the USA between 2008-2017. Eight of these cases were contracted outside of the U.S. and its territories.

May 8, 2018 - KEDRAB [Rabies Immune Globulin (Human)] has been launched in the U.S., and initial shipments are now reaching healthcare practitioners across the country. Deliveries have been timed to meet the growing demand for this product as the height of the 2018 spring/summer rabies season approaches.